The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development

ABSTRACT: Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for signal activation, whose activity is mediated through the receptor complex and a scaffold protein Dishevelled (Dsh). We report here that the exon junction complex (EJC) activity is indispensable for Wg signaling by maintaining an appropriate level of Dsh protein for Wg ligand reception in Drosophila. Transcriptome analyses in Drosophila wing imaginal discs indicate that the EJC controls the splicing of the cell polarity gene disc large 1 (dlg1), whose coding protein directly interacts with Dsh. Genetic and biochemical experiments demonstrate that Dlg1 protein acts independently from its role in cell polarity to protect Dsh protein from ly

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Ruifeng Li 

PROVIDER: E-GEOD-81220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress