β-cateinin activation in hair follicle dermal sheath induces ectopic hair outgrowth and skin fibrosis

ABSTRACT: Dermal sheath (DS) shows potent hair inducing capability and high plasticity without leading to immuno rejection. A recent study showed a subset of DS cells, identified as hair follicle (HF) dermal stem cells, can be mobilized to regenerate DS, maintain/supply the cell number of dermal papilla (DP) and modulate hair type. However, it is unclear how Wnt/β-catenin signaling regulates DS cells behaviors. Here we report that activation of β-catenin in DS, to some extent, endows it with hair inducing ability, reprogramming HF epidermal cells to generate new outgrowth. The new formed dermal condensates (DC)/DP lying adjacent the outgrowth derives from DS and/or its progeny, and homeostasis of pre-existing HFs is disturbed. Additionally, progressive skin fibrosis is prominent in hypodermis, whe

ORGANISM(S): Mus musculus

SUBMITTER: Yi Tao 

PROVIDER: E-GEOD-81615 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress