The transcriptional landscape of mouse blood stem/progenitor cell transitions at single cell resolution

ABSTRACT: Current gene-expression databases for the haematopoietic system provide information on gene expression profiles present in bulk populations. Although informative, these studies lack the resolution that can be gained at a single-cell level. In particular, population-average data assumes homogeneity within the population and may as such obscure the ability to detect the heterogeneity of decision-making processes in individual cells. Here we report 1656 single cell transcriptomes analysed by single-cell RNA sequencing. Cells were FACS sorted on broad gates encompassing haematopoietic stem and progenitor populations (HSPCs), with index sorting data collected to permit retrospective identification of populations by surface marker expression. Our dataset thus represents the gene expression lands

ORGANISM(S): Mus musculus

SUBMITTER: Evangelia Diamanti 

PROVIDER: E-GEOD-81682 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress