An epigenetic mark of polycomb response elements implemented by Trx/MLL/COMPASS

ABSTRACT: In Drosophila, Polycomb Response Elements (PREs) are identified as genomic sequences allowing the maintenance of transcriptional repression in the absence of the initiating signal. Although PREs in Drosophila are well characterized, the existence of mammalian PRE-like elements remains debated. Accumulating evidence supports a model in which CpG islands function to recruit Polycomb-Group complexes (PcG), however, it is not evident which subclasses of CpG islands serve as PREs. Trithorax (Trx), which is required for positive regulation of gene expression in Drosophila, is known to co-bind Drosophila PREs where it is thought to antagonize polycomb-dependent silencing of nearby genes. Here, we demonstrate the existence of Trx-dependent H3K4 dimethylation loci that specifically mark Drosophil

ORGANISM(S): Homo sapiens

SUBMITTER: Ali Shilatifard 

PROVIDER: E-GEOD-81795 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress