Transcription profiling of mouse fetal heart from wild type and Estrogen-related Receptor gamma (ERRg) knockout strains

ABSTRACT: 3 ventricles from E18.5 male mice were pooled for each array. Three arrays per genotype. Title: ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Post-Natal Heart; Abstract: At birth the heart undergoes a critical metabolic switch to transition from a predominant dependence on carbohydrates during fetal life to a greater dependence on postnatal oxidative metabolism. This remains the principle metabolic state throughout life; although pathologic conditions such as heart failure and cardiac hypertrophy reactivate components of the fetal genetic program to increase carbohydrate utilization. Disruption of the ERRγ gene, which is expressed at high levels in the fetal and postnatal mouse heart, blocks this switch resulting in lactatemia, electrocardiographic (ECG) abnorm

ORGANISM(S): Mus musculus

SUBMITTER: Ronald Evans 

PROVIDER: E-GEOD-8199 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress