Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNAseq

ABSTRACT: The striatum contributes to many cognitive processes and disorders, but its cell types are incompletely characterized. We show that microfluidic and FACS-based single-cell RNA sequencing of mouse striatum provides a well-resolved classification of striatal cell type diversity. Transcriptome analysis revealed 10 differentiated distinct cell types, including neurons, astrocytes, oligodendrocytes, ependymal, immune, and vascular cells, and enabled the discovery of numerous novel marker genes. Furthermore, we identified two discrete subtypes of medium spiny neurons (MSN) which have specific markers and which overexpress genes linked to cognitive disorders and addiction. We also describe continuous cellular identities, which increase heterogeneity within discrete cell types. Finally, we identif

ORGANISM(S): Mus musculus

SUBMITTER: Stephen Quake 

PROVIDER: E-GEOD-82187 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress