Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene Expression Profile in Developing Mouse Brain Following Chronic Hypoxia Treatment

ABSTRACT: In this study, we determined the effect of chronic consistent hypoxia (CCH) and chronic intermittent hypoxia (CIH) on global gene expression in cortical and hippocampal region of developing mouse brain using long-oligo beadschip arrays. Keywords: Gene expression profile Control-Cortex: Cortical samples from 16 days old mice were analysed on whole-genome expression chips to reveal expression profile at this developmental stage. Used as control for Chronic Hypoxia Treated cortical samples. CCH-Cortex: Cortical samples from 2-week CCH treated mice were analysed on whole-genome expression chips to reveal the changes in gene expression profile following 2-week CCH treatment. CIH-Cortex: Cortical samples from 2-week CCH treated mice were analysed on whole-genome expression chips to reveal the changes in gene expression profile following 2-week CIH treatment. Control-Hippocampus: Hippocampal samples from 16 days old mice were analysed on whole-genome expression chips to reveal expression profile at this developmental stage. Used as control for Chronic Hypoxia Treated hippocampal samples. CCH-Hippocampus: Hippocampal samples from 2-week CCH treated mice were analysed on whole-genome expression chips to reveal the changes in gene expression following 2-week CCH treatment. CIH-Hippocampus: Hippocampal samples from 2-week CCH treated mice were analysed on whole-genome expression chips to reveal the changes in gene expression following 2-week CIH treatment.

ORGANISM(S): Mus musculus

SUBMITTER: Dan Zhou 

PROVIDER: E-GEOD-8262 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death.

Zhou Dan D   Wang Jiyi J   Zapala Matthew A MA   Xue Jin J   Schork Nicholas J NJ   Haddad Gabriel G GG  

Physiological genomics 20071204 3

Hypoxia is a hallmark of respiratory, neurological, or hematological diseases as well as life at high altitude. For example, chronic constant hypoxia (CCH) occurs in chronic lung diseases or at high altitude, whereas chronic intermittent hypoxia (CIH) occurs in diseases such as sleep apnea or sickle cell disease. Despite the fact that such conditions are frequent, the cellular and molecular mechanisms underlying the effect of hypoxia, whether constant or intermittent, are not well understood. In  ...[more]

Similar Datasets

Transcriptomics Gene Expression Profile in Developing Mouse Brain Following Chronic Hypoxia Treatment
2007-12-04 | GSE8262 | GEO
Transcriptomics FGF2 stimulation experiment with CF1 mouse embryonic fibroblasts
2006-10-03 | GSE5437 | GEO
Transcriptomics Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia
2010-06-10 | E-GEOD-2271 | biostudies-arrayexpress
Transcriptomics FGF2 stimulation experiment with NMRI mouse embryonic fibroblasts
2006-10-03 | GSE5436 | GEO
Transcriptomics FGF2 stimulation experiment with CD1 mouse embryonic fibroblasts
2006-10-03 | GSE5435 | GEO
Transcriptomics Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia
2005-04-18 | GSE2271 | GEO
Transcriptomics Chronic hypoxia alters the level, maturation and control of gene expression in mouse kidney
2005-09-13 | GSE3289 | GEO
Transcriptomics Gene expression in clavicular cortical hyperostosis
2021-04-15 | GSE172049 | GEO
Transcriptomics Hippocampal gene network analysis to determine the effects of coral calcium hydride in an experimental model of accelerated senescence
2011-09-22 | E-GEOD-31606 | biostudies-arrayexpress
Proteomics Unbiased proteomic study of the axons of cultured rat cortical neurons
2018-04-17 | PXD005527 | Pride