Transcription profiling of human monocytes to macrophage differentiation

ABSTRACT: Macrophages play a critical role in the pathogenesis of many diseases, including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Monocytes recruited into tissues from peripheral blood differentiate into macrophages. There is limited data concerning the global changes in the expression of genes during monocyte to macrophage, and how the patterns of change identify the mechanism contributing to differentiation or macrophage function. Employing the microarray technology, we examined the transcriptional profile of in vitro adherence-induced differentiation of primary human monocytes into macrophages. We found the significant up regulation of genes contributing to the functions of macrophage, including signature patterns defining the induction of genes contributing to

ORGANISM(S): Homo sapiens

SUBMITTER: Bo Shi 

PROVIDER: E-GEOD-8286 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress