Transcription profiling of mouse monocytes recruited in the peritoneum during experimental infection with Listeria monocytogenes

ABSTRACT: The immune system cellular response to tissue damage and infection requires the recruitment of blood leukocytes to the target tissue. This process is mediated through a classical multistep mechanism which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We show here, by direct examination of blood monocyte functions in vivo, that resident monocytes monitor the endothelium of healthy tissues through patrolling, a new mechanism which allows extravasation in the absence of rolling.Patrolling depends on the integrin LFA1 and the chemokine receptor CX3CR1, and is required for rapid tissue invasion and initiation of an early immune response by monocytes that differentiate into macrophages at the site of tissue damage and infection. The main

ORGANISM(S): Mus musculus

SUBMITTER: Silvia Rueberg 

PROVIDER: E-GEOD-8294 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress