Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: implications for treatment-resistance

ABSTRACT: Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less-known. We found that an epigenetic and energetic agent, acetyl-L-carnitine (LAC, oral administration), rapidly rescued the depressive- and central and systemic metabolic-like phenotype of LAC-deficient Flinders Sensitive Line (FSL) rats. After acute stress during LAC treatment, a subset of FSL continued to respond to LAC (rFSL), whereas the other subset did not respond (nrFSL). RNAseq for the ventral dentate-gyrus (vDG), a mood-regulatory region, identified metabolic factors as key markers predisposing to depression (insulin receptors Insr, glucose transporters Glut-4 and Glut-12, the regulator of appetite Cartpt) and to LAC responsiveness (

ORGANISM(S): Rattus norvegicus

SUBMITTER: Carla Nasca 

PROVIDER: E-GEOD-83336 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress