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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Analysis of aerobic and resistance training-induced changes in human vastus lateralis gene expression

ABSTRACT: The purpose of this study was to use global gene expression to identify skeletal muscle genes that correlate with exercise-induced Si changes. Longitudinal cohorts from the Studies of Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) were utilized for vastus lateralis gene expression profiles. Si was determined via intravenous glucose tolerance test pre- and post-training. Pearson product-moment correlation coefficients determined relationships between a) baseline and b) training-induced changes in gene expression and Si after training. Total RNA extracted from human vastus lateralis prior-to and following 8 months of structured aerobic and resistance training

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Barberio

PROVIDER: E-GEOD-83352 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analysis of aerobic and resistance training-induced changes in human vastus lateralis gene expression

Project description:The purpose of this study was to use global gene expression to identify skeletal muscle genes that correlate with exercise-induced Si changes. Longitudinal cohorts from the Studies of Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) were utilized for vastus lateralis gene expression profiles. Si was determined via intravenous glucose tolerance test pre- and post-training. Pearson product-moment correlation coefficients determined relationships between a) baseline and b) training-induced changes in gene expression and Si after training.

2016-06-30 | GSE83352 | GEO

Metabolic syndrome exercise training

Project description:We assessed vastus lateralis muscle gene expression levels of 12 women with the metabolic syndrome before and after a 6 month exercise training program RNA was isolated from a vastus lateralis muscle biopsy of 6 women with the metabolic syndrome before and after a 6 month guided endurance exercise training program

2013-11-05 | E-GEOD-43760 | biostudies-arrayexpress

Metabolic syndrome exercise training

Project description:We assessed vastus lateralis muscle gene expression levels of 12 women with the metabolic syndrome before and after a 6 month exercise training program

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Metabolic syndrome exercise training

Project description:We assessed vastus lateralis muscle gene expression levels of 6 women with the metabolic syndrome before and after a 6 month exercise training program

2015-05-31 | GSE46697 | GEO

Gene expression changes in skeletal muscle following aerobic exercise training

Project description:Microarray analysis was performed with RNA isolated from vastus lateralis muscle biopsies of lean/overweight subjects following 18 days of aerobic exercise training. Samples from lean active individuals were also included. Exercise training led to robust changes in trained muscle. The lean active group profile was distinct from the pre-exercise samples. These results help define the molecular changes associated with aerobic training and contrast with an active phenotype.

2020-05-01 | GSE139258 | GEO

Muscle Transcriptional Networks Linked to Resistance Exercise Training Hypertrophic Response Heterogeneity

Project description:Bulk polyA-RNAseq was performed on vastus lateralis muscle samples from older adults ≥65y at baseline and post-14 wk resistance exercise training (high-low-high intensity). The primary study used network biology algorithms to create gene networks of highly connected transcripts, and then linked these to change in muscle size induced by exercise training.

2021-06-01 | GSE163434 | GEO

Effects of resistance exercise and resistance training on the skeletal muscle transcriptome in young and old adults

2012-02-21 | GSE28422 | GEO

The Effects of Regular Post-Exercise Cold Water Immersion on DNA methylation in Muscle Following 10-weeks of Strength Training

Project description:In this study, the primary objective was to characterise the impact of regular post-exercise (20 strength training sessions across 10 weeks) cold-water immersion (CWI) on DNA methhylation. Secondary to this, the effect of regular post-exercise CWI on strength gains and post-exercise soreness was investigated. We used microarrays to detail the global effects of CWI on DNA methylation in vastus lateralis muscle tissue.

2016-08-16 | GSE85621 | GEO

The Effects of Regular Post-Exercise Cold Water Immersion on Gene Expression in Muscle Following 10-weeks of Strength Training

Project description:In this study, the primary objective was to characterise the impact of regular post-exercise (20 strength training sessions across 10 weeks) cold-water immersion (CWI) on mRNA expression. Secondary to this, the effect of regular post-exercise CWI on strength gains and post-exercise soreness was investigated. We used microarrays to detail the global effects of CWI on gene expression in vastus lateralis muscle tissue.

2016-08-16 | GSE85620 | GEO

Effects of resistance exercise and resistance training on the skeletal muscle transcriptome in young and old adults

Project description:Global microarray (HG U133 Plus 2.0) was used to investigate the effects of resistance exercise and resistance training on the skeletal muscle transcriptome profile of 28 young and old adults. Vastus lateralis muscle biopsies were obtained pre and 4hrs post resistance exercise in the beginning (untrained state) and at the end (trained state) of a 12 wk progressive resistance training program. A total of 28 subjects were included in this investigation. The young (n=16, 24±1y) participants included 8 males and 8 females. The old (n=12, 84±1y) participants included 6 males and 6 females. All subjects participated in 12 wks of progressive resistance training consisting of bilateral knee extensions with 3x10 reps at 70% of 1-RM, and 3d/wk for a total of 36 training sessions. Vastus lateralis biopsies were obtained in conjunction with the 1st and 36th (last) training session and included a basal biopsy and another biopsy 4hrs post the resistance exercise session (for a total of 4 biopsies per subject). The RNA integrity for all samples was very good with an average RIN number of 7.6. All 110 samples were analyzed on a separate microarray chip, and samples were not pooled between subjects. The study design allowed us to examine the acute effects of resistance exercise on the skeletal muscle transcriptome in the untrained and trained state. The design also provided information on the effects of resistance training on basal level gene expression and the effects of age on basal level gene expression

2012-02-21 | E-GEOD-28422 | biostudies-arrayexpress

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