POLRMT regulates the switch between replication-primer formation and gene expression of mammalian mtDNA

ABSTRACT: Mitochondria are vital in providing cellular energy via their oxidative phosphorylation system, which requires the coordinated expression of genes encoded by both the nuclear and mitochondrial genomes (mtDNA). Transcription of the circular mammalian mtDNA depends on a single mitochondrial RNA polymerase (POLRMT). Although the transcription initiation process is well understood, it remains highly controversial if POLRMT also serves as the primase for initiation of mtDNA replication. In the nucleus, the RNA polymerases needed for gene expression have no such role. Conditional knockout of Polrmt in heart results in severe mitochondrial dysfunction causing dilated cardiomyopathy in young mice. We further studied the molecular consequences of different expression levels of POLRMT and found that

ORGANISM(S): Mus musculus

SUBMITTER: Stefan Siira 

PROVIDER: E-GEOD-83368 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress