Transcription profiling of moise cochlear after noise-induced changes in strains differing in their susceptibility to noise damage

ABSTRACT: The molecular mechanisms underlying the great differences in susceptibility to noise-induced hearing loss (NIHL) exhibited by both humans and laboratory animals are unknown. Using microarray technology, the present study demonstrates that the effects of noise overexposure on the expression of molecules likely to be important to the development of NIHL differ among inbred mice that have distinctive susceptibilities to NIHL including B6.CAST, 129X1/SvJ, and 129S1/SvImJ. The noise-exposure protocol produced, on average, a permanent loss of about 40 dB in sensitivity for auditory brainstem responses in susceptible B6.CAST mice, but no threshold elevations for the two resistant 129S1/SvImJ and 129X1/SvJ substrains. Measurements of noise-induced gene expression changes 6 h after the noise exp

ORGANISM(S): Mus musculus

SUBMITTER: Ana Elena Vazquez 

PROVIDER: E-GEOD-8342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress