Transcription profiling of S. cerevisiae xylose metabolism mutants grown on glucose and xylose under aerobic and anaerobic conditions
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Thomas William Jeffries
PROVIDER: E-GEOD-835 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Saccharomyces cerevisiae engineered for xylose metabolism exhibits a respiratory response.
Jin Yong-Su YS Laplaza Jose M JM Jeffries Thomas W TW
Applied and environmental microbiology 20041101 11
Native strains of Saccharomyces cerevisiae do not assimilate xylose. S. cerevisiae engineered for d-xylose utilization through the heterologous expression of genes for aldose reductase (XYL1), xylitol dehydrogenase (XYL2), and d-xylulokinase (XYL3 or XKS1) produce only limited amounts of ethanol in xylose medium. In recombinant S. cerevisiae expressing XYL1, XYL2, and XYL3, mRNA transcript levels for glycolytic, fermentative, and pentose phosphate enzymes did not change significantly on glucose ...[more]
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