Sex-specific Variation in Signaling Pathways and Gene Expression Patterns in Human Leukocytes in Response to Endotoxin and Exercise

ABSTRACT: While exercise effects on the immune system received increasing attention in recent years, it remains unclear to what extent gender and fluctuations in sex hormones during menstrual cycle influence immunological responses to exercise. Using a previously published microarray data set, we investigated mRNA changes induced through exhaustive exercise (half-marathon; pre-exercise and post-exercise [30 min, 3h, 24h], whole blood culture ± LPS (1h)) with a specific focus on sex differences (women in luteal phase vs men). Inflammation related pathways, TLRs, cytosolic DNA sensing and RIG-I like receptors were differentially activated between sexes in LPS-stimulated cultures. Genes differentially regulated between sexes included TNIP-1, TNIP-3, IL-6, HIVEP1, CXCL3, CCR3, IL-8 and CD69, reveal

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Walter 

PROVIDER: E-GEOD-83578 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress