Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Drosophila Clockwork Orange rveals it is a transcriptional repressor and a new Drosophila circadian pacemaker component (GEO super series)

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE7644: CLKGR in S2 cells; GSE7646: CLK targets from fly heads; GSE7651: Timepoints 5073 strain; GSE7652: Timepoints Control strain; GSE7653: S2 cells transfected with Clk Experiment Overall Design: Refer to individual Series

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sebastian Kadener 

PROVIDER: E-GEOD-8391 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component.

Kadener Sebastian S   Stoleru Dan D   McDonald Michael M   Nawathean Pipat P   Rosbash Michael M  

Genes & development 20070619 13

Many organisms use circadian clocks to keep temporal order and anticipate daily environmental changes. In Drosophila, the master clock gene Clock promotes the transcription of several key target genes. Two of these gene products, PER and TIM, repress CLK-CYC-mediated transcription. To recognize additional direct CLK target genes, we designed a genome-wide approach and identified clockwork orange (cwo) as a new core clock component. cwo encodes a transcriptional repressor that synergizes with PER  ...[more]

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