Cis sequence effects on gene expression

ABSTRACT: Sequence and transcriptional variability within and between individuals are typically studied independently. The joint analysis of sequence and gene expression variation provides insight into biological mechanisms that underlie gene regulation and function. We investigated the role of sequence variation in cis on gene expression (cis sequence effects) in a group of genes frequently studied in cancer research. We assessed the proportion of genes exhibiting cis sequence effects and the proportion of gene expression variation explained by cis sequence effects, and compared our results to the literature. Keywords: genetical genomics Thirty lymphoblastoid cell lines drawn from the SNP500Cancer resource were cultured in triplicate. The intersection of gene expression profiling data at N=697 c

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Bergen 

PROVIDER: E-GEOD-8394 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress