Comparative genomic hybridization proling of human Ewing Sarcoma tumour samples (26)

ABSTRACT: Ewing’s Sarcoma (ES) is characterized by specific chromosomal translocations, the most common being t(11;22)(q24;q12). Additionally, other types of genetic abnormalities may occur and be relevant to explain the variable tumoural biology and clinical outcome. We have carried out a high-resolution array CGH and expression profiling on 25 ES tumour samples to characterize the DNA copy number aberrations (CNA) occurring in these tumours and to determine their association with gene expression profiles (GEO Series accession number: GSE8303) and their clinical outcome. CNA were observed in 84% of the cases. We observed a median number of 3 aberrations per case. Besides numerical chromosomal changes, smaller aberrations were found and defined at chromosomes 5p, 7q and 9p. All CNA were compiled

ORGANISM(S): Homo sapiens

SUBMITTER: Juan Cigudosa 

PROVIDER: E-GEOD-8398 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress