Characterization of gene expression profile in HBV-related liver fibrosis patients

ABSTRACT: Hepatitis B virus (HBV) infection is a leading risk factor for liver fibrosis (LF) and hepatocellular carcinoma. Emerging evidence indicates that host genetic, virological and immunological factors will influence the fibrotic progress. Many previous studies have focused on specific pathways or genes included in LF mechanism, however global view of the whole genome expresion profile in HBV related LF patients never been studied, and the mechanisms underlying the promotion of liver fibrosis progression remain obscure. Here we collected liver biopsy samples from 124 chronic hepatitis B (CHB) patients and used Affymetrix HG U133 Plus 2.0 microarray to quantify the transcriptome of these patients. Through integrated data analysis, including geneset enrichment analysis (GSEA), weighted gene co-e

ORGANISM(S): Homo sapiens

SUBMITTER: Mingjie Wang 

PROVIDER: E-GEOD-84044 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress