Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Age Map, Cerebellum (A)

ABSTRACT: To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged and old mice. Mice of both genders were examined as well as the effects of their placement on either caloric restricted (CR) or ad libitum (AL) diets. Keywords: age-, gender-, and diet- comparison 67 mice were compared according to age, gender, and diet

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Becker

PROVIDER: E-GEOD-8409 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender.

Xu Xiangru X Zhan Ming M Duan Wenzhen W Prabhu Vinayakumar V Brenneman Randall R Wood William W Firman Jeff J Li Huai H Zhang Peisu P Ibe Carol C Zonderman Alan B AB Longo Dan L DL Poosala Suresh S Becker Kevin G KG Mattson Mark P MP

Genome biology 20070101 11

<h4>Background</h4>The structural and functional complexity of the mammalian central nervous system (CNS) is organized and modified by complicated molecular signaling processes that are poorly understood.<h4>Results</h4>We measured transcripts of 16,896 genes in 5 CNS regions from cohorts of young, middle-aged and old male and female mice that had been maintained on either a control diet or a low energy diet known to retard aging. Each CNS region (cerebral cortex, hippocampus, striatum, cerebell ...[more]

PMID: 17988385

Publication: 1/2

Dataset Information

Age Map, Cerebellum (A)

Publications

Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender.

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