The PAXX and XLF DNA Repair Factors are Functionally Redundant in Joining DNA breaks in a G1-arrested Progenitor B Cell Line

ABSTRACT: Classical non-homologous end-joining (C-NHEJ) is a major mammalian DNA double strand break (DSB) repair pathway. Core C-NHEJ factors, such as XRCC4, are required for joining DSB intermediates of the G1 phase-specific V(D)J recombination reaction in progenitor lymphocytes. Core factors also contribute to joining DSBs in cycling mature B-lineage cells, including DSBs generated during antibody class switch recombination (CSR) and DSBs generated by ionizing radiation (IR). The XLF C-NHEJ factor is dispensable for V(D)J recombination in normal cells, but, due to functional redundancy, is absolutely required for this process in cells deficient for the ATM DSB response factor. The recently identified PAralogue of XRCC4 and XLF (PAXX) factor has homology to these two proteins and variably contr

ORGANISM(S): Mus musculus

SUBMITTER: Richard Frock 

PROVIDER: E-GEOD-84102 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress