Transcription profiling of rat adrenal zona glomerulosa cells stimulated with aldosterone secretagogues

ABSTRACT: The mineralocorticoid aldosterone mainly produced by the adrenal gland is essential for life but an abnormal excessive secretion causes severe pathological effects including hypertension and target organ injury in the heart and kidney. The aim of this study was to determine the gene regulatory network triggered by aldosterone secretagogues in a non transformed cell system. Freshly isolated rat adrenal zona glomerulosa cells were stimulated with the two main aldosterone secretagogues, angiotensin II and potassium, for two hours and subjected to whole genome expression studies using multiple biological and bioinformatics tools. Several genes were differentially expressed by Ang II (n=133) or potassium (n=216). Genes belonging to the nucleic acid binding and transcription factor activity cate

ORGANISM(S): Rattus norvegicus

SUBMITTER: Damian Gaston Romero 

PROVIDER: E-GEOD-8421 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress