Transcription profiling of human skeletal muscle from 55-80 year old individuals fed low and high protein diets

ABSTRACT: Inadequate dietary protein intake causes adverse changes in the morphology and function of skeletal muscle. These changes may be reflected in early alterations in muscle mRNA levels. Microarray analysis was used to assess whether inadequate protein intake differentially affects skeletal muscle transcript levels and expression profiles in older adults. Experiment Overall Design: 11 older males and females (aged 55-80 y) consumed controlled diets that contained 1.2 g protein•kg-1•d-1 (adequate protein) for one wk and then 0.5 g protein•kg-1•d-1 (inadequate protein; IP group; n=11) for a second wk. RNA was isolated from fasting-state vastus lateralis biopsies obtained at the end of each period and the transcript levels were determined using the Affymetrix U133A array

ORGANISM(S): Homo sapiens

SUBMITTER: Wayne Campbell 

PROVIDER: E-GEOD-8441 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress