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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of hormone sensitive and hormone refractory human prostate cancer xenografts grown in mice

ABSTRACT: Seven pairs of hormone sensitive and hormone refractory prostate cancer xenografts

ORGANISM(S): Homo sapiens

SUBMITTER: Charlie Chen

PROVIDER: E-GEOD-847 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular determinants of resistance to antiandrogen therapy.

Chen Charlie D CD Welsbie Derek S DS Tran Chris C Baek Sung Hee SH Chen Randy R Vessella Robert R Rosenfeld Michael G MG Sawyers Charles L CL

Nature medicine 20031221 1

Using microarray-based profiling of isogenic prostate cancer xenograft models, we found that a modest increase in androgen receptor mRNA was the only change consistently associated with the development of resistance to antiandrogen therapy. This increase in androgen receptor mRNA and protein was both necessary and sufficient to convert prostate cancer growth from a hormone-sensitive to a hormone-refractory stage, and was dependent on a functional ligand-binding domain. Androgen receptor antagoni ...[more]

PMID: 14702632

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