INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer [RNA-seq]

ABSTRACT: Epigenetic regulators are attractive targets for the development of new cancer therapies. Among them, the ATP-dependent chromatin remodeling complexes control the chromatin architecture and play important roles in gene regulation. They are often found to be mutated and de-regulated in cancers, but how they influence the cancer gene expression program during cancer initiation and progression is not fully understood. Here we show that the INO80 chromatin remodeling complex is required for oncogenic transcription and tumor growth in non-small cell lung cancer (NSCLC). Ino80, the SWI/SNF ATPase in the complex, is highly expressed in NSCLC cells compared to normal lung epithelia cells. Further, its expression, as well as that of another subunit Ino80b, negatively correlates with disease prognos

ORGANISM(S): Homo sapiens

SUBMITTER: Li Wang 

PROVIDER: E-GEOD-85118 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress