Intra-individual tumoral heterogeneity of ovarian serous adenocarcinomas [Illumina]

ABSTRACT: Intra-individual tumoral heterogeneity (ITH) is a hallmark of solid tumors and impedes accurate genomic diagnosis and selection of proper therapy. The purpose of this study was to identify ITH of ovarian serous adenocarcinomas (OSAs) and to determine the utility of ascitic cancer cells as a resource for mutation profiling in spite of ITH. We performed whole-exome sequencing, copy number profiling, and DNA methylation profiling of four OSA genomes using multiregional biopsies from 13 intraovarian lesions, 12 extraovarian tumor lesions (omentum/peritoneum), and ascitic cells. We observed substantial levels of heterogeneity in mutations and copy number alterations (CNAs) of the OSAs. We categorized the mutations into 'common', 'shared' and 'private' according to the regional distribution. Six

ORGANISM(S): Homo sapiens

SUBMITTER: Je-Keun Rhee 

PROVIDER: E-GEOD-85293 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress