Genome-wide transcriptome analyses by RNAseq to determine the change that happens in the peripheral taste system with age.

ABSTRACT: To understand the mechanisms that regulate the renewal and maintenance of taste cells we performed RNA-sequencing analysis on isolated taste cells from 2 and 6 month old mice to determine how alterations in the taste cell-transcriptome regulate taste cell maintenance and function in adults. We found that the Activator Protein-1 (AP1) transcription factors (c-Fos, Fosb and c-Jun) and genes associated with this pathway were significantly downregulated in taste cells from 6 month old mice and further declined at 12 months. We generated conditional c-Fos- knockout mice to target K14-expressing cells, including differentiating taste cells. c-Fos deletion caused a severe perturbation in taste bud structure and resulted in a significant reduction in the taste bud size. c-Fos deletion also affect

ORGANISM(S): Mus musculus

SUBMITTER: Jayasha Shandilya 

PROVIDER: E-GEOD-85308 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress