Histone Arginine Methylation in Cocaine Action: Essential Role of Src Signaling in the Nucleus Accumbens

ABSTRACT: Despite addiction being one of the most prevalent and debilitating disorders worldwide, effective treatments are lacking. Repeated cocaine exposure induces maladaptive transcriptional regulation within the brainâ??s reward circuitry, such as the nucleus accumbens (NAc), and epigenetic mechanisms, such as histone acetylation or methylation on Lys (K) residues, have been linked to these lasting actions of cocaine. However, in contrast to K methylation, the functional role of histone Arg (R) methylation remains unexplored in addiction models and poorly understood in brain in general. Here we show that protein-R-methyltransferase-6 (PRMT6) and its associated histone mark, asymmetric dimethylation of R2 on histone H3 (H3R2me2a), are decreased in the NAc of mice and rats after repeated cocaine e

ORGANISM(S): Mus musculus

SUBMITTER: Eric Nestler 

PROVIDER: E-GEOD-85310 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress