Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis

ABSTRACT: Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. There are two types of AMD: dry AMD and wet AMD. While laser-induced choroidal neovascularization has been used extensively in the studies of wet AMD by presenting the main features of human wet AMD, there was no established mouse model which fully recapitulates the cardinal features of human dry AMD. In this regard, lack of appropriate mouse model for dry AMD hampered the translational research on the pathogenesis and development of therapeutic agents. We recently suggested that 5XFAD mice could be a mouse model of dry AMD with regard to the amyloid beta (Aβ) related pathology. In this study, using transmission electron microscope, we analyzed ultrastructure of retinal pigment epithelium (RPE) of 5XFAD

ORGANISM(S): Mus musculus

SUBMITTER: Sung Wook Park 

PROVIDER: E-GEOD-85408 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress