Genetic Susceptibility to Diabetic Nephropathy is Related to Pro-inflammatory Pathways

ABSTRACT: Diabetic nephropathy (DN) is a leading cause of ESRD worldwide, but its molecular pathogenesis is not well-defined and there are no specific treatments. In humans, there is a strong genetic component determining susceptibility to DN. However, specific genes controlling DN susceptibility in humans have not been identified. Here we describe a new mouse model, combining type 1 diabetes with activation of the renin angiotensin system (RAS), which develops robust kidney disease with features resembling human DN: heavy albuminuria, hypertension and glomerulosclerosis. Additionally, there is a powerful effect of genetic background regulating susceptibility to nephropathy. The 129 strain is susceptible to kidney disease, whereas the C57BL/6 strain is resistant. To examine the molecular basis of th

ORGANISM(S): Mus musculus

SUBMITTER: Sujoy Ghosh 

PROVIDER: E-GEOD-85569 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress