Transcription profiling of human breat cancer cell lines reveals XBP1 confers estrogen independence and antiestrogen resistance

ABSTRACT: Human X-box binding protein-1 (XBP1) is an alternatively spliced transcription factor that participates in the unfolded protein response (UPR), a stress signaling pathway that allows cells to survive the accumulation of unfolded proteins in the endoplasmic reticulum lumen. We have previously demonstrated that XBP1 expression is increased in antiestrogen-resistant breast cancer cell lines, and is co-expressed with estrogen receptor alpha (ER) in breast tumors. The purpose of this study is to investigate the role of XBP1 and the UPR in estrogen and antiestrogen responsiveness in breast cancer. Overexpression of spliced XBP1 (XBP1(S)) in ER-positive breast cancer cells leads to estrogen-independent growth and reduced sensitivity to growth inhibition induced by the antiestrogens Tamoxifen an

ORGANISM(S): Homo sapiens

SUBMITTER: Rebecca Riggins 

PROVIDER: E-GEOD-8562 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress