Transcription profiling of mouse lymphtoxin beta receptor-deficient thymic medullary epithelial cells vs. wild-type and Aire-deficient vs wild-type littermates

ABSTRACT: We compared gene expression profiles of lymphotoxin alpha- and lymphtoxin beta receptor-deficient thymic medullary epithelial cells with their wild-type littermates, as well as with Aire-deficient and wild-type littermates. This was done in order to determine whether there was overlap in the effects of lymphotoxin and aire. Experiment Overall Design: Individual thymi were digested with collagenase, dispase and DNAse, and meduallary epithelial cells with the phenotype CD45-G8.8+Ly51intMHCclasssIIhi were isolated by FACS.

ORGANISM(S): Mus musculus

SUBMITTER: CBDM Lab 

PROVIDER: E-GEOD-8563 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress