Comprehensive Genomic Characterization of Five Canine Lymphoid Tumor Cell Lines

ABSTRACT: Background Leukemia/lymphoma cell lines have been critical in the investigation of the pathogenesis and therapy of hematological malignancies. While human LL cell lines have generally been found to recapitulate the primary tumors from which they were derived, appropriate characterization including cytogenetic and transcriptional assessment is crucial for assessing their clinical predictive value. Results In the following study, five canine LL cell lines, CLBL-1, Ema, TL-1 (Nody-1), UL-1, and 3132, were characterized using extensive immunophenotyping, karyotypic analysis, oligonucleotide array comparative genomic hybridization (oaCGH), and gene expression profiling. Genome-wide DNA copy number data from the cell lines were also directly compared with 299 primary canine round cell tumors

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Steven Suter 

PROVIDER: E-GEOD-85720 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress