The Long Noncoding RNA SNHG1 Regulates both the Local and Distal Genes in Cancer

ABSTRACT: lncRNAs play important roles in various physiological and pathological processes. However, the detailed molecular mechanisms by which lncRNAs act are still incomplete. Here, we functionally characterized the nuclear-enriched lncRNA SNHG1 which is highly expressed in several types of cancer relative to surrounding normal tissues. SNHG1 was regulated by oncogenic factor c-Myc and could promote tumor growth. We found that SNHG1 was involved in the Akt signaling pathway through promoting the neighboring transcription of protein-coding gene SLC3A2 in cis, by binding to the Mediator complex to facilitate enhancer-promoter interaction. Transcriptome analysis further revealed that several stress response genes, as well as signaling pathways, were regulated by SNHG1. Importantly, SNHG1 coordinated

ORGANISM(S): Homo sapiens

SUBMITTER: Guifeng Wei 

PROVIDER: E-GEOD-85842 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress