Combined arrayCGH and SNP-loss of heterozygosity analysis in cervical cancer

ABSTRACT: BACKGROUND: Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker analysis for the detection of loss of heterozygosity (LOH). Currently, high throughput methods such as array comparative genomic hybridization (array CGH), single nucleotide polymorphism array (SNP array) and gene expression arrays are available to study genome-wide alterations. Integration of these 3 platforms allows detection of genomic alterations at high resolution and investigation of an association between copy number changes and expression. RESULTS: Genome-wide copy number and genotype analysis of 10 cervical cancer cell lines by array

ORGANISM(S): Homo sapiens

SUBMITTER: Judith Kloth 

PROVIDER: E-GEOD-8605 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress