Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human kidney glomerular and tubular progenitor cells

ABSTRACT: Multipotent progenitor cells (MPs) have been observed in human kidneys and particularly in Bowman's capsule and proximal tubules. The kidney owns the ability to repair local damage and renal MPs may play a role in the regenerative processes. Microarray technology was applied to identify differentially expressed genes among resident MPs isolated from glomeruli and tubules of normal renal tissue, renal proximal tubular epithelial cells (RPTECs) and mesenchymal stem cells (MSCs). The results of our analysis represent a starting point for further functional studies. Experiment Overall Design: This study includes three renal tissue samples which were processed to obtain 3 glomerular progenitor populations and 3 tubular ones. Three subcoltures of MSCs and RPTECs were included as well. The differences in gene expression patterns of the 4 cell types were found out.

ORGANISM(S): Homo sapiens

SUBMITTER: Fabio Sallustio 

PROVIDER: E-GEOD-8611 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

TLR2 plays a role in the activation of human resident renal stem/progenitor cells.

Sallustio Fabio F   De Benedictis Luc L   Castellano Giuseppe G   Zaza Gianluigi G   Loverre Antonia A   Costantino Vincenzo V   Grandaliano Giuseppe G   Schena Francesco P FP  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091020 2

In the past few years, adult renal progenitor/stem cells (ARPCs) have been identified in human kidneys, and particularly in Bowman's capsule and proximal tubules. They may play an important role in the kidney regenerative processes and might prospectively be the ideal cell type for the treatment of both acute and chronic renal injury. In this study, microarray analysis identified 6 gene clusters that discriminated normal human glomerular and tubular ARPCs from renal proximal tubular epithelial c  ...[more]

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