Regulation of the Mycobacterium tuberculosishypoxic response gene encoding alpha-crystallin

ABSTRACT: Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic conditions within the host, but the response of M. tuberculosis to a hypoxic signal remains poorly characterized. The M. tuberculosis alpha-crystallin (acr) gene is powerfully and rapidly induced at reduced oxygen tensions, providing us with a means to identify regulators of the hypoxic response. Using a whole genome microarray, we identified >100 genes whose expression is rapidly altered by defined hypoxic conditions. Numerous genes involved in biosynthesis and aerobic metabolism are repressed, where

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER: D Sherman 

PROVIDER: E-GEOD-8639 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress