The Mycobacterium tuberculosis ECF sigma Factor sE: role in global gene expression and survival in macrophages

ABSTRACT: In previously published work, we identified three Mycobacterium tuberculosis sigma (s) factor genes responding to heat shock (sigB, sigE and sigH ). Two of them (sigB and sigE ) also responded to SDS exposure. As these responses to stress suggested that the s factors encoded by these genes could be involved in pathogenicity, we are studying their role in physiology and virulence. In this work, we characterize a sigE mutant of M. tuberculosis H37Rv. The sigE mutant strain was more sensitive than the wild-type strain to heat shock, SDS and various oxidative stresses. It was also defective in the ability to grow inside both human and murine unactivated macrophages and was more sensitive than the wild-type strain to the killing activity of activated murine macrophages. Using microarray technol

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER: SMD Staff 

PROVIDER: E-GEOD-8664 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress