SiRNA profiling of Zebrafish embryos silenced by zfPGRP-SC

ABSTRACT: Peptidoglycan recognition proteins (PGRPs) are a family of pattern recognition receptors (PRRs) that serve as a strong link between invertebrate and vertebrate immunity.It has been demonstrated that PGRPs in insects function as bacterial recognition molecules which trigger proteolytic or signal transduction pathways, being thus important in the antimicrobial innate immunity. To explore the effect of zebrafish short-form PGRP (zfPGRP-SC) on proteolytic or signal transduction pathway, RNA interference (siRNA) and high-density oligonucleotide microarray methods were used to identify differentially expressed genes regulated by zfPGRP-SC. Experiment Overall Design: The control siRNA, zfPGRP-SC siRNA were introduced into zebrafish zygotes at the concentration of 300 ng / μl under a normal micro

ORGANISM(S): Danio rerio

SUBMITTER: M Chang 

PROVIDER: E-GEOD-8724 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress