Genetic alteration in recurrent melanoma

ABSTRACT: It is generally accepted that human cancers derive from a mutated single cell. However, the genetic steps characterizing various stages of progression remain unclear. Studying a unique case of metastatic melanoma, we observed that cell lines derived from metachronous metastases arising over a decade retained a central core of genetic stability in spite of divergent phenotypes. In the present study we expanded our previous observations comparing these autologous cell lines of clonal derivation with heterologous ones and correlated array Comparative Genomic Hybridization (aCGH) with gene expression profiling to determine their relative contribution to the dynamics of disease progression. aCGH and gene expression profiling were performed on autologous cell lines and heterologous melanoma cell

ORGANISM(S): Homo sapiens

SUBMITTER: Francesco Marincola 

PROVIDER: E-GEOD-8777 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress