Transcription profiling of human haptocytes infected with plasmodium reveals circumsporozoite protein promotes the development of the liver stages of the Parasite

ABSTRACT: The liver stages of malaria sporozoites develop in the hepatocyte cytoplasm inside a parasitophorous vacuole (PV). The circumsporozoite (CS) protein, the major surface protein of sporozoites, traverses the PV membrane and enters the cytoplasm and nucleus of hepatocytes. CS export into the cytoplasm requires the presence of pexel/VTS motifs. The transport of CS into the host nucleus is then mediated by importin (Imp) alpha3/beta1 that binds to the nuclear localization signal of CS localized in the conserved region II-plus. The NLSs of CS and of NFkB p50 share the same Imp. The entry of NFkB p50 into the nucleus is strongly inhibited in cell lines expressing CS, and in infected hepatocytes. Micro-array data from CS expressing cell line shows that 40 NFkB targets were significantly down regu

ORGANISM(S): Homo sapiens

SUBMITTER: John Walker 

PROVIDER: E-GEOD-8784 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress