Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John Walker
PROVIDER: E-GEOD-8784 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell 20071101 3
The liver stages of malaria are clinically silent but have a central role in the Plasmodium life cycle. Liver stages of the parasite containing thousands of merozoites grow inside hepatocytes for several days without triggering an inflammatory response. We show here that Plasmodium uses a PEXEL/VTS motif to introduce the circumsporozoite (CS) protein into the hepatocyte cytoplasm and a nuclear localization signal (NLS) to enter its nucleus. CS outcompetes NFkappaB nuclear import, thus downregula ...[more]