ANALYSIS OF GENE EXPRESSION IN EARLY-STAGE OVARIAN CANCER (2)

ABSTRACT: Gene expression was analysed in 68 stage I ovarian cancers and 15 borderline samples using microarrays. Tumors were obtained directly at surgery and immediately frozen in liquid nitrogen until analysis. Glass arrays containing 16000 genes were used. Data was interpreted by unsupervised and supervised analysis. All tumors had a wild-type p53. Unsupervised analysis identified eight major clusters one of which was statistically associated to overall survival, grading and histotype (cluster C) and another with grading and histotype (cluster D). Supervised analysis showed a clear association between histotypes and gene expression profile and distinguished the four major histotypes (serous, clear cells, mucinous, endometrioid). The data also discriminated between the different grades of the tumo

ORGANISM(S): Homo sapiens

SUBMITTER: Pietro Mariani 

PROVIDER: E-GEOD-8842 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress