Gene expression analysis of chronically inflamed human peri-implant and periodontal ligament cells in vivo

ABSTRACT: The goal of this study was to compare the gene expression profiles of chronically inflamed human peri-implant and chronically inflamed human periodontal tissues in order to elucidate potential changes at the molecular level. Cells out of the pocket depth of the inflamed peri-implant and periodontal ligament as well as from the middle third of healthy periodontal ligament were applied. Genome-wide gene expression was compared with the help of microarray analysis, and the data were validated by real-time RT-PCR. The expression rates of 14,239 genes were investigated and 2,079 of them were found differentially expressed by at least two-fold; the expression rates of 1,093 genes were significantly up-regulated and the expression rates of 986 genes were significantly down-regulated in inflamed p

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Geffers 

PROVIDER: E-GEOD-8908 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress