Transcription profiling of mouse testicular response to recombinant follicle stimulating hormone (rFSH) in hypogonadal males

ABSTRACT: In the normal mouse the pituitary gonadotrophins determine development, maturation and physiological regulation of the testis with follicle-stimulating hormone (FSH) activating the Sertoli cell and luteinising hormone (LH) the Leydig cell. To look at the potential interaction of cell types within the testis following hormone stimulation we have investigated the effect of rFSH on testicular gene expression in the hypogonadal (hpg) male mouse. Due to a deletion in the gene encoding gonadotrophin-releasing hormone (GnRH), FSH and LH levels are at the lower limit of detection in the circulation and mice remain in a pre-pubertal state throughout life unless given exogenous hormone. Here we have addressed important question of changes in the global gene expression profile of testicular tissue f

ORGANISM(S): Mus musculus

SUBMITTER: Dilair Baban 

PROVIDER: E-GEOD-8924 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress