Genome-wide characterization of light-inducible responses reveals a hierarchical light-sensing cascade in N. crassa

ABSTRACT: To better understand the roles of WC-1, WC-2 and other putative photoreceptors in mediation of light signals and to identify new components in light sensing cascades, we used microarrays with genome-wide coverage to characterize light-inducible transcriptional changes in Neurospora crassa. After unsupervised hierarchical clustering of 90 microarrays, 316 genes, representing about 3.21% of the total genome, showed robust and consistent light responses. As expected, WC-1 and WC-2 knockout strains both exhibited severe impairments in response to a continuous white light stimulus, confirming their dominant roles in light sensing cascades. Knockout strains of 5 newly-identified light-inducible transcription factors were further characterized for their potential function in mediating light signa

ORGANISM(S): Neurospora crassa

SUBMITTER: Chen-Hui Chen 

PROVIDER: E-GEOD-8932 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress