Transcription profiling of human bone marrow and adipose tissue-derived stromal cells

ABSTRACT: Bone marrow (BM) has been considered so far the reference source for stromal cells (SC) originally called mesenchymal stem cells. Recently human adult adipose tissue (AT) has been reported as a valuable source for the isolation of cells exerting a mesenchymal-like phenotype. Though both BM- and AT- derived stromal cells (BMSC and ATSC) share similar immuno-phenotype and exhibit multi-lineage potential in vitro, a consensual panel of specific markers is still debated and the precise molecular mechanisms governing their differentiated fate are not fully understood. The aim of this study was to compare the genome wide expression profiles of stromal cells isolated from AT and BM and to emphasize the core of MSC stemness properties. Moreover we focused on the molecular characteristics of ATSC,

ORGANISM(S): Homo sapiens

SUBMITTER: Nathalie Saulnier 

PROVIDER: E-GEOD-8954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress