Transcription profiling of mouse liver to identify gene expression associated with Strain-Specific Ehrlichia chaffeensisa induced Hepatitis

ABSTRACT: Infection of humans with Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis, can cause hepatitis of varying severity. When the three human isolates of E. chaffeensis, each belongs to different geno-groups, are inoculated into severe combined immunodeficiency mice, the severity of clinical signs and bacterial burden detected in the liver are strain Wakulla>Liberty>Arkansas. Disseminated and granulomatous inflammation is evident in the liver of mice infected with strains Wakulla and Arkansas, respectively, but not in mice infected with strain Liberty. In this paper, we used microarray analysis to define transcriptional profiles characteristic to the histopathological features in the mouse liver. Cytokine and chemokine profiles were strikingly different among three str

ORGANISM(S): Mus musculus

SUBMITTER: Koshiro Miura 

PROVIDER: E-GEOD-8966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress