A novel approach to investigate tissue-specific trinucleotide repeat instability - A validation set of prediction model

ABSTRACT: In Huntington’s disease (HD), an expanded CAG repeat produces characteristic striatal neurodegeneration. Interestingly, the HD CAG repeat, whose length determines age at onset, undergoes tissue-specific somatic instability, predominant in the striatum, suggesting that tissue-specific CAG length changes could modify the disease process. Therefore, understanding the mechanisms underlying the tissue specificity of somatic instability may provide novel routes to therapies. However progress in this area has been hampered by the lack of sensitive high-throughput instability quantification methods and global approaches to identify the underlying factors. Here we describe a novel approach to gain insight into the factors responsible for the tissue specificity of somatic instability. Using accurat

ORGANISM(S): Mus musculus

SUBMITTER: Jong-Min Lee 

PROVIDER: E-GEOD-9025 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress