Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Anton Glück
PROVIDER: E-GEOD-9037 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
European journal of immunology 20080301 3
IRAK-4 kinase inactive (IRAK-4 KD) knock-in mice display defects in TLR- and IL-1 receptor signaling and are resistant to LPS-induced shock. In the present study we examined the LPS-induced response in IRAK-4 KD mice in more detail. We show that IRAK-4 kinase activity is required for certain aspects of TLR-mediated signaling but not for others. We found that IRAK-4 KD cells displayed reduced JNK and p38 signaling, while NF-kappaB was activated to a normal level but with delayed kinetics compared ...[more]