Transcription profiling of human MCF-7 breast cancer cells transfected with TGFBR1*6A the hypomorphic variant of TGFBR1 to identify genes in the genes in the migratory pathway

ABSTRACT: TGFBR1*6A is a common hypomorphic variant of the type 1 Transforming Growth Factor Beta Receptor (TGFBR1), which has been associated with increased cancer risk in some studies. Although TGFBR1*6A is capable of switching TGF-β growth inhibitory signals into growth stimulatory signals when stably transfected into MCF-7 breast cancer cells, TGFBR1*6A biological effects are largely unknown. To broadly explore TGFBR1*6A potential oncogenic properties, we assessed its impact on the migration and invasion of MCF-7 cells. We found that TGFBR1*6A significantly enhances MCF-7 cell migration and invasion in a TGF-β signaling independent manner. We set up and performed a gene array using the conditions mimicking the cell migration experiments to determine which genes in the migratory pathway were

ORGANISM(S): Homo sapiens

SUBMITTER: Boris Pasche 

PROVIDER: E-GEOD-9093 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress